The role of Wnt signaling in male reproductive physiology and pathology

Abstract Accumulating evidence has shown that Wnt signaling is deeply involved in male reproductive physiology, and malfunction of the signal path can cause pathological changes genital organs sperm cells. These abnormalities are diverse manifestation have been constantly found knockout models studies. Nevertheless, most research solely focused on a certain factor pathway, there few reports overall relation between signals physiology. In our review, findings relating to system were sought summarized terms ligands, receptors, intracellular regulators. By sorting out integrating relevant functions, as well underlining controversies among different reports, review aims offer an overview physiology pathology for further mechanistic